Effect of metalaxyl on heart rate in rats: role of alpha 1-adrenoreceptors.
IR@CFTRI: CSIR-Central Food Technological Research Institute, Mysore
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http://ir.cftri.com/2363/
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| Title |
Effect of metalaxyl on heart rate in rats: role of alpha 1-adrenoreceptors.
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| Creator |
Naidu, K. A.
Radhakrishnamurty, R. |
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| Subject |
26 Pesticide Chemistry
17 Toxicology |
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| Description |
Intraperitoneal injection of metalaxyl (250 mg/kg) produced a decrease in heart rate lasting for more than 60 min in anesthetized rats. Pretreatment of rats with phentolamine (a nonselective alpha-adrenoreceptor antagonist, ip at 20 mg/kg) and prazosin (an alpha 1-adrenoreceptor antagonist, ip at 5 mg/kg) significantly reduced the bradycardia induced by metalaxyl. Yohimbine (an alpha 2-adrenoreceptor antagonist, ip at 10 mg/kg) did not change the effect of metalaxyl on heart rate. The results suggest that alpha 2-adrenoreceptors mediate the bradycardic effect of metalaxyl.
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| Date |
1989
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Article
PeerReviewed |
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| Format |
pdf
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| Language |
en
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| Identifier |
http://ir.cftri.com/2363/1/Journal%20of%20Toxicology%20and%20Environmental%20Health%2C%2026203-207%2C%201989.pdf
Naidu, K. A. and Radhakrishnamurty, R. (1989) Effect of metalaxyl on heart rate in rats: role of alpha 1-adrenoreceptors. Journal of Toxicology and Environmental Health, 26 (2). pp. 203-7. ISSN 0098-4108 |
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