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Biochemical changes produced by beta- and gamma-hexachlorocyclohexane isomers in albino rats.

IR@CFTRI: CSIR-Central Food Technological Research Institute, Mysore


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Relation	http://ir.cftri.com/2368/

Title	Biochemical changes produced by beta- and gamma-hexachlorocyclohexane isomers in albino rats.

Creator	Srinivasan, K. Radhakrishnamurty, R.

Subject	07 Enzyme Biochemistry 17 Toxicology

Description	Administration of beta- and gamma-isomers of hexachlorocyclohexane (HCH) at 800 ppm dietary level for 2 weeks to albino rats produced noticeable hepatocellular damage as indicated by elevations in serum aminotransferases and decreases in hepatic soluble enzymes. Although serum total LDH activity was not altered, the LD5 isoenzyme was proportionately higher in the HCH isomers treated animals. Treatment of rats with beta- and gamma-isomers of HCH increased the hepatic glucose-6-phosphate dehydrogenase and aldolase activities suggesting a higher rate of glucose oxidation. Liver glucose-6-phosphatase activity was decreased in these animals indicating inactivation of gluconeogenesis in liver. Dietary beta- and gamma-HCH decreased the liver mitochondrial DNP/Mg++/Ca++-activated ATPases thus affecting the energy metabolism. An unaltered ratio of DNP/Mg++-ATPase, a study of swelling pattern of hepatic mitochondria, and NAD+ permeability test suggested the maintenance of structural integrity of mitochondrial membrane in these pesticide fed animals. Liver microsomal Na+,K+-ATPases were lower in these animals.

Date	1988

Type	Article PeerReviewed

Format	pdf

Language	en

Identifier	http://ir.cftri.com/2368/1/J%20.%20ENVIRON.%20SCI.%20HEALTH%2C%20B23%284%29%2C%20367-386%20%281988%29.pdf Srinivasan, K. and Radhakrishnamurty, R. (1988) Biochemical changes produced by beta- and gamma-hexachlorocyclohexane isomers in albino rats. Journal of Environmental Science and Health. Part. B, Pesticides, food contaminants, and agricultural wastes, 23 (4). pp. 367-86. ISSN 0360-1234