Inhibition of monoamine oxidase-A of rat brain by pyrethroids--an in vitro kinetic study.
IR@CFTRI: CSIR-Central Food Technological Research Institute, Mysore
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http://ir.cftri.com/2287/
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| Title |
Inhibition of monoamine oxidase-A of rat brain by pyrethroids--an in vitro kinetic study.
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| Creator |
Rao, G. V.
Rao, K. S. J. |
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| Subject |
26 Pesticide Chemistry
17 Toxicology |
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| Description |
An in vitro kinetic study on inhibition of the monoamine oxidase-A (MAO-A) of the rat brain by two pyrethroids, namely permethrin (PM) and cypermethrin (CPM), has shown that PM and CPM competitively inhibit MAO-A by altering both the Michaelis-Menten constant (Km) and the maximum velocity (Vmax). Inhibitor constant values (Ki) indicated that CPM was a more effective inhibitor of MAO-A than PM. Both PM and CPM caused maximum inhibition of MAO-A at neutral pH. CPM significantly elevated the activation energy values of MAO-A as compared to those of PM.
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| Date |
1993
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| Type |
Article
PeerReviewed |
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| Format |
pdf
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| Language |
en
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| Identifier |
http://ir.cftri.com/2287/1/Molecular%20and%20Cellular%20Biochemistry%20124%20107-114%2C%201993.pdf
Rao, G. V. and Rao, K. S. J. (1993) Inhibition of monoamine oxidase-A of rat brain by pyrethroids--an in vitro kinetic study. Molecular and Cellular Biochemistry, 124 (2). pp. 107-14. ISSN 0300-8177 |
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