Effect of vitamin A on hexachlorocyclohexane (HCH) toxicity in the rat.
IR@CFTRI: CSIR-Central Food Technological Research Institute, Mysore
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http://ir.cftri.com/2305/
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| Title |
Effect of vitamin A on hexachlorocyclohexane (HCH) toxicity in the rat.
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| Creator |
Joseph, P.
Shivanandappa, T. Narasimhamurthy, K. Krishnakumari, M. K. |
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| Subject |
26 Pesticide Chemistry
17 Toxicology 04 Vitamins |
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| Description |
1. Technical hexachlorocyclohexane (HCH) depleted hepatic stores of vitamin A in male albino rats to cause secondary vitamin A deficiency. 2. Toxicity of HCH in rats is augmented by dietary vitamin A-deficiency as evidenced by growth retardation, organ hypertrophies and alterations in the serum and liver levels of the marker enzymes of toxicity. 3. Supplementation of dietary vitamin A to the rats either in adequate (2000 IU/kg diet) or in an excess but not hypervitaminotic level (10(5) IU/kg diet) resulted in significant protection against the toxicity of HCH. 4. The activities of the hepatic xenobiotic metabolizing enzymes were generally low (with the exception of glutathione S-transferase) in the vitamin A-deficient rats compared to those of the vitamin A supplemented diet groups. 5. The results indicated that dietary vitamin A influences the response of male albino rats to HCH toxicity possibly by modulating the activities of hepatic xenobiotic metabolizing enzymes.
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| Date |
1992
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Article
PeerReviewed |
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pdf
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| Language |
en
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| Identifier |
http://ir.cftri.com/2305/1/Gen%20Pharmac%20Vol%2023%2C%20No%206%2C%20pp%201159-1164%2C%201992.pdf
Joseph, P. and Shivanandappa, T. and Narasimhamurthy, K. and Krishnakumari, M. K. (1992) Effect of vitamin A on hexachlorocyclohexane (HCH) toxicity in the rat. General Pharmacology, 23 (6). pp. 1159-64. ISSN 0306-3623 |
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