A lipoxygenase inhibitor from Aspergillus niger.
IR@CFTRI: CSIR-Central Food Technological Research Institute, Mysore
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http://ir.cftri.com/2111/
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| Title |
A lipoxygenase inhibitor from Aspergillus niger.
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| Creator |
Sekhar Rao, K. C.
Divakar, S. Appu Rao, A. G. Karanth, N. G. Sattur, A. P. |
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| Subject |
05 Enzymes
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| Description |
A lipoxygenase-1 (LOX-1) inhibitor was isolated from the fermented broth of Aspergillus niger CFTRI 1105. It was purified, using column and preparative thin layer chromatography. 1H NMR and GC-MS examination revealed the structure of the inhibitor to be 2-(2'-methyl, 4'-hydroxyphenyl), 2-(4"hydroxyphenyl)-propane with a molecular weight of 242 and the molecular formula C,6H18O2. This bisphenol-derivative inhibitor shows 50% inhibition of soybean LOX-I at 0.98 mM concentration. The activity of this inhibitor was compared with commercial bisphenol A and its structural analogues, butylhydroxyanisole and butylhydroxytoluene in an attempt to understand the role of functional groups affecting lipoxygenase activity.
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| Date |
2002
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Article
PeerReviewed |
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| Format |
pdf
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| Language |
en
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| Identifier |
http://ir.cftri.com/2111/1/Appl%20Microbiol%20Biotechnol%20%282002%29%2058%20539%E2%80%93542.pdf
Sekhar Rao, K. C. and Divakar, S. and Appu Rao, A. G. and Karanth, N. G. and Sattur, A. P. (2002) A lipoxygenase inhibitor from Aspergillus niger. Applied Microbiology and Biotechnology, 58 (4). pp. 539-42. ISSN 0175-7598 |
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