Metalaxyl-induced bradycardia in rats: mediated by alpha-adrenoreceptors.
IR@CFTRI: CSIR-Central Food Technological Research Institute, Mysore
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http://ir.cftri.com/2377/
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| Title |
Metalaxyl-induced bradycardia in rats: mediated by alpha-adrenoreceptors.
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| Creator |
Naidu, K. A.
Radhakrishnamurty, R. |
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26 Pesticide Chemistry
17 Toxicology |
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| Description |
The effect of the fungicide metalaxyl [methyl N-(2-methoxyacetyl)-N-(2,6-xylyl)-DL-alaniate] on cardiac activity was investigated in albino rats anesthetized with phentobarbitone. Metalaxyl caused dose-dependent bradycardia, and at higher doses (250 and 300 mg/kg body weight) the sustained bradycardia led to cardiac arrest. The acetylcholinesterase activities in brain and heart were not affected in metalaxyl-treated rats. However, the bradycardia induced by the fungicide was blocked by pretreatment of rats with the alpha-adrenoreceptor antagonist phentolamine (20 mg/kg, ip). The data suggest that the bradycardia-inducing effect of metalaxyl was not mediated by the cholinergic system but through alpha-adrenoreceptors.
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| Date |
1988
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Article
PeerReviewed |
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| Format |
pdf
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| Language |
en
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| Identifier |
http://ir.cftri.com/2377/1/Journal%20of%20Toxicology%20and%20Environmental%20Health%2C%2023495-498%2C%201988.pdf
Naidu, K. A. and Radhakrishnamurty, R. (1988) Metalaxyl-induced bradycardia in rats: mediated by alpha-adrenoreceptors. Journal of Toxicology and Environmental Health, 23 (4). pp. 495-8. ISSN 0098-4108 |
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