Cardiotoxic effects of dichlorvos (DDVP) in albino rats.
IR@CFTRI: CSIR-Central Food Technological Research Institute, Mysore
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http://ir.cftri.com/2382/
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| Title |
Cardiotoxic effects of dichlorvos (DDVP) in albino rats.
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| Creator |
Naidu, K. A.
Viswanatha, S. Krishnakumari, M. K. |
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| Subject |
26 Pesticide Chemistry
17 Toxicology |
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| Description |
Dichlorvos (O, O-dimethyl O-(2,2-dichlorovinyl phosphate: DDVP 76.6 X EC) an organophosphate pesticide had a profound effect on cardiac activity of albino rats. Adult male rats anesthetized with pentobarbitone were administered 30, 50, 70 and 90 mg/kg body weight of dichlorvos. The heart rate and electrocardiogram were monitored and acetylcholinesterase activity was measured in heart and brain. Dichlorvos produced abnormalities in ECG, decrease in heart rate, cardiac arrest and inhibition of cholinesterase activity. It is suggested that cardiotoxic effect of DDVP may be mediated by the accumulated acetylcholine as a result of cholinesterase inhibition.
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| Date |
1987
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Article
PeerReviewed |
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| Format |
pdf
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| Language |
en
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| Identifier |
http://ir.cftri.com/2382/1/Indian%20journal%20of%20physiology%20and%20pharmacology%2C%2031%20%281%29.%20pp.%2019-24.pdf
Naidu, K. A. and Viswanatha, S. and Krishnakumari, M. K. (1987) Cardiotoxic effects of dichlorvos (DDVP) in albino rats. Indian Journal of Physiology and Pharmacology, 31 (1). pp. 19-24. ISSN 0019-5499 |
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