Swallow root (Decalepis hamiltonii) pectic oligosaccharide (SRO1) induces cancer cell death via modulation of galectin-3 and surviving.
IR@CFTRI: CSIR-Central Food Technological Research Institute, Mysore
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| Relation |
http://ir.cftri.com/13551/
https://doi.org/10.1016/j.carbpol.2018.01.053 |
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| Title |
Swallow root (Decalepis hamiltonii) pectic oligosaccharide (SRO1) induces
cancer cell death via modulation of galectin-3 and surviving.
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| Creator |
Mallikarjuna, S. E.
Dharmesh, Shylaja M |
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| Subject |
28 Polysaccharide Chemistry
Swallow root |
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| Description |
Swallow root pectic oligosaccharide fraction (SRO1) from swallow root pectic polysaccharide (SRPP) possessed a
molecular size of 831 Da. Structural analysis revealed that it is a rhamnogalacturonan I type, bearing arabinogalactan
side chain with β-D-(1→4) galactose along with α-L-Araf (1→5)-α-L-Araf (1→3) structure on α-D-GalAOAc-(
1→2)-α-L-Rha-(1→4)- linear backbone. β-D (1→4) linked galactose being the specific sugar for galectin-3,
SRO1 had potentials in inhibiting galectin-3 mediated cancer progression. SRO1 inhibited galectin-3 mediated
agglutination, in vitro, effectively with MIC of 1.08 μg/ mL and down regulated mRNA levels of galectin-3
(∼92%) along with its downstream key protein that inhibits apoptosis – survivin (∼78%) suggesting the capability
of SRO1 in inhibiting galectin-3 mediated cancer promoting pathway. This is the first report, which
highlights the inhibition of interplay of galectin-3 and survivin by a dietary pectic oligosaccharide.
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| Date |
2018
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| Type |
Article
PeerReviewed |
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| Format |
pdf
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| Language |
en
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| Identifier |
http://ir.cftri.com/13551/1/Carbohydrate%20Polymers%20186%20%282018%29%20402%E2%80%93410.pdf
Mallikarjuna, S. E. and Dharmesh, Shylaja M (2018) Swallow root (Decalepis hamiltonii) pectic oligosaccharide (SRO1) induces cancer cell death via modulation of galectin-3 and surviving. Carbohydrate Polymers, 186. pp. 402-410. |
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