Hypolipidemic and Antioxidant Properties of Oryzanol Concentrate in Reducing Diabetic Nephropathy via SREBP1 Downregulation Rather than β-Oxidation.
IR@CFTRI: CSIR-Central Food Technological Research Institute, Mysore
View Archive Info| Field | Value | |
| Relation |
http://ir.cftri.com/13587/
https://dx.doi.org/10.1002/mnfr.201700511 |
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| Title |
Hypolipidemic and Antioxidant Properties of Oryzanol
Concentrate in Reducing Diabetic Nephropathy via SREBP1
Downregulation Rather than β-Oxidation.
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| Creator |
Bhaskaragoud, G.
Geetha, V. Sharanappa, T. Mohan Kumar, A. S. Hemakumar, C. Suresh Kumar, G. |
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| Subject |
11 Lipid Biochemistry
04 Diabetes Mellitus |
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| Description |
Scope: Diabetic nephropathy (DN) is a micro-vascular complication of
chronic diabetes. Sterol regulatory element binding protein1 (SREBP1)
participation in the development of DN is reported. Oryzanol concentrate
(OC) at 0.1% and 0.3% is tested for its antioxidant and hypolipidemic effects.
The aim of the work is to study the involvement of OC in the amelioration of
DN in STZ-induced diabetic animal model.
Methods and results: Animals were grouped into starch, high-fat, and
OC-treated control/diabetic groups (SFC/SFD, HFC/HFD, OFC/OFD). The
markers of DN, increased glomerular filtration rate and kidney weight, were
evident in HFD and reduced in OFD group by �1.09 and �1.3 fold,
respectively. The amelioration of defensive antioxidant enzyme activities and
lipid peroxidation, expressions of lipid-associated biomolecules (SREBP1 and
FAS) were also observed. HFD showed increased ECM accumulation of
glycoproteins, particularly Type IV collagen, fibronectin. SREBP1-associated
gene transforming growth factor-β (TGF-β) was reduced on treatment (OFD
� 1.3 fold) as to HFD (�2.7 fold).
Conclusion: Oryzanol concentrate, having hypolipidemic and antioxidant
properties, also downregulated the lipid biosynthesis through reduced
SREBP1–TGF-β interactions (EMSA) and could effectively ameliorate DN.
Gene (ACC2, Cpt1, and ACOX) expression studies showed that β-oxidation
was not involved in reducing DN.
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| Date |
2018
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| Type |
Article
PeerReviewed |
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| Format |
pdf
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| Language |
en
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| Identifier |
http://ir.cftri.com/13587/1/Molecular_Nutrition_%2526_Food_Research.pdf
Bhaskaragoud, G. and Geetha, V. and Sharanappa, T. and Mohan Kumar, A. S. and Hemakumar, C. and Suresh Kumar, G. (2018) Hypolipidemic and Antioxidant Properties of Oryzanol Concentrate in Reducing Diabetic Nephropathy via SREBP1 Downregulation Rather than β-Oxidation. Molecular Nutrition and Food Research, 62. pp. 101-11. ISSN 1613-4125 |
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