Fabrication of a nutrient delivery system of docosahexaenoic acid nanoemulsions via high energy techniques.
IR@CFTRI: CSIR-Central Food Technological Research Institute, Mysore
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| Relation |
http://ir.cftri.com/13808/
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| Title |
Fabrication of a nutrient delivery system of
docosahexaenoic acid nanoemulsions via high
energy techniques.
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| Creator |
Karthik, P.
Anandharamakrishnan, C. |
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| Subject |
17 Fatty Acid Chemistry
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| Description |
Docosahexaenoic acid (DHA) is the key omega-3 fatty acid for the growth and development of the human
brain and retina and is inevitable for heart health. DHA is highly susceptible to environmental factors due to
its increased oxidation and physical instability; therefore, preventing and extending its shelf life is highly
required. DHA can be made stable in terms of its chemical and kinetic attributes with the help of
nanoemulsion systems. In this study, a DHA nanoemulsion was prepared via an oil-in-water emulsion
using Tween-40 emulsifier, through high speed homogenization (HSH), high pressure homogenization
(HPH) and combination of the HSH + HPH techniques. The stability of the nanoemulsion was
investigated using physiochemical methods under different storage conditions. The fabricated
nanoemulsions were less than 88 nm in size with globular droplets having higher negative charges of
�31.1 and �30.2 mV, which were produced by the combination and HPH technique, respectively. Higher
Newtonian flow behavior was observed for the combination and HPH technique. The functional groups
of DHA remained intact without undergoing any changes and functional activity during the
nanoemulsification process, which was evident from the unchanged fatty acids profile. Similarly, there
were no structural changes observed in all the DHA emulsions. The refrigerated (4 � 1 �C) emulsion
exhibited lower lipid oxidation than those stored at the temperature of 28 � 1 �C and 40 � 0.2 �C.
Combination of the homogenization techniques was found to result in better physiochemical properties
and stability over a period of 100 days during storage than the other emulsification techniques for the
encapsulation of DHA.
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| Date |
2016
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| Type |
Article
PeerReviewed |
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| Format |
pdf
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| Language |
en
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| Identifier |
http://ir.cftri.com/13808/1/RSC%20Advances%202016.pdf
Karthik, P. and Anandharamakrishnan, C. (2016) Fabrication of a nutrient delivery system of docosahexaenoic acid nanoemulsions via high energy techniques. RSC Advances, 6. pp. 3501-3513. |
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