Lack of genotoxic effects of piperine, (the active principle of black pepper) in albino mice.
IR@CFTRI: CSIR-Central Food Technological Research Institute, Mysore
View Archive Info| Field | Value | |
| Relation |
http://ir.cftri.com/8010/
JFS-04-90 |
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| Title |
Lack of genotoxic effects of piperine, (the active principle of black pepper) in albino mice.
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| Creator |
Muralidhara, Dr.
Narasimhamurthy, K. |
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| Subject |
30 Spices/Condiments
17 Toxicology |
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| Description |
The potency of piperine, the active principle of black pepper, to induce micronuclei in bone-marrow erythrocytes and dominant-lethal mutations was investigated in male mice. Preliminary studies indicated that piperine administered intraperitoneally to adult male mice at sublethal doses of 1, 2 or 4 mg/kg body wt. (1/20, 1/10 or 1/5 LD50) on 5 consecutive days did not induce any clinical signs of toxicity or any significant alterations in epididymal wt., testicular wt. or testicular histology. In bone-marrow micronucleus assay, piperine induced no significant increase in micronuclei in polychromatic erythrocytes, suggesting its nonclastogenic nature at tested doses. It also failed to induce dominant-lethal mutations during an 8-wk sequential mating schedule of males at a dosage of 4 mg/kg body wt./day for 5 days. Caudal sperm counts and the incidence of sperm-head abnormalities measured at 1, 3, 5 and 7 wk were not altered in piperine administered males at any of the doses.
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| Date |
1990
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Language |
en
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| Identifier |
http://ir.cftri.com/8010/1/Journal_of_Food_Safety_11%281%29_1990_39-48.pdf
Muralidhara, Dr. and Narasimhamurthy, K. (1990) Lack of genotoxic effects of piperine, (the active principle of black pepper) in albino mice. Journal of Food Safety, 11 (1). pp. 39-48. |
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