Effect of micellar lipids, dietary fiber and β-carotene on lutein bioavailability in aged rats with lutein deficiency.
IR@CFTRI: CSIR-Central Food Technological Research Institute, Mysore
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http://ir.cftri.com/10541/
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| Title |
Effect of micellar lipids, dietary fiber and β-carotene on lutein bioavailability in
aged rats with lutein deficiency.
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| Creator |
Mamatha, Bangera Sheshappa
Baskaran, V. |
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| Subject |
13 Nutrition-Human
04 Vitamins |
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| Description |
Objective: To determine the effect of various dietary components on the intestinal uptake of lutein
in aged rats.
Methods: This study determined the time-course (2, 4, 6, 8 h) plasma and tissue responses of
a pharmacologic dose of lutein (200 mM) solubilized in mixed micelles with fat (3%, soybean oil),
phosphatidylcholine (PC; 3 mM), lysophosphatidylcholine (lysoPC; 3 mM), dietary fiber (pectin,
1.25%), b-carotene (200 mM), or micelles with no dietary components (control) in aged rats with
lutein deficiency.
Results: No lutein was detected in the plasma of rats at 0 h indicating the deficiency. After gavages
of lutein, the mean percent area under the curve (picomoles per milliliter per 8 h) of plasma lutein
in the fat (91.4), PC (218.0), and lysoPC (94.1) groups were higher (P > 0.05), whereas its level in the
dietary fiber and b-carotene groups was lower than the control group. The liver and eye lutein
levels of the PC (95.4, 38.67%) and fat (18.2, 143%) groups were significantly higher, whereas the
lysoPC (9.6, 27.2%), b-carotene (19.2, 35.4%), and dietary fiber (3.1, 88.4%) groups were lower than
the control group.
Conclusion: Results indicate that soybean oil and soy phospholipids greatly sway lutein absorption
in aged rats with lutein deficiency. The results also suggest that ingestion of lutein with pectin and
b-carotene suppresses lutein absorption. Hence, to improve the absorption of lutein in older adults
with macular pigment deficiency, foods with sufficient fat with low dietary fiber and b-carotene
may be suggested.
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| Date |
2011
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Language |
en
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| Identifier |
http://ir.cftri.com/10541/1/Nutrition%2C%20Volume%2027%2C%20Issue%209%2C%20September%202011%2C%20Pages%20960-966.pdf
Mamatha, Bangera Sheshappa and Baskaran, V. (2011) Effect of micellar lipids, dietary fiber and β-carotene on lutein bioavailability in aged rats with lutein deficiency. Nutrition, 27. pp. 960-966. |
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