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Protection against hydrogen peroxide induced oxidative damage in rat erythrocytes by Mangifera indica L. peel extract

IR@CFTRI: CSIR-Central Food Technological Research Institute, Mysore

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Title Protection against hydrogen peroxide induced oxidative damage in rat erythrocytes by Mangifera indica L. peel extract
 
Creator Ajila, C. M.
Prasada Rao, U. J. S.
 
Subject 06 Mango
18 Phytochemistry
 
Description Phytochemicals such as polyphenols and carotenoids are gaining importance because of their contribution to human health and their multiple biological effects such as antioxidant, antimutagenic, anticarcinogenic and cytoprotective activities and other therapeutic properties. Mango peel is a major by-product in pulp industry and it contains various bioactive compounds like polyphenols, carotenoids and others. In the present study, the protective effect of peel extracts of unripe and ripe mango fruits of two varieties namely, Raspuri and Badami on hydrogen peroxide induced hemolysis, lipid peroxidation, degradation of membrane proteins and its morphological changes are reported. The oxidative hemolysis of rat erythrocytes by hydrogen peroxide was inhibited by mango peel extract in a dose dependent manner. The IC50 value for lipid peroxidation inhibition on erythrocyte ghost membrane was found to be in the range of 4.5–19.3 lg gallic acid equivalents. The mango peel extract showed protection against membrane protein degradation caused by hydrogen peroxide. Morphological changes to erythrocyte membrane caused by hydrogen peroxide were protected by mango peel extract. The results demonstrated that mango peel extracts protected erythrocytes against oxidative stress and may impart health benefits and it could be used as a valuable food ingredient or a nutraceutical product.
 
Date 2008
 
Type Article
PeerReviewed
 
Format application/pdf
 
Language en
 
Identifier http://ir.cftri.com/8711/1/Food_and_Chemical_Toxicology_46%281%29_2008_303-309.pdf
Ajila, C. M. and Prasada Rao, U. J. S. (2008) Protection against hydrogen peroxide induced oxidative damage in rat erythrocytes by Mangifera indica L. peel extract. Food and Chemical Toxicology, 46 (1). pp. 303-309.