Antiulcer And Anticancer Bioactive Compounds From Ginger (Zingiber Officinale) And Mango Ginger (Curcuma Amada)
IR@CFTRI: CSIR-Central Food Technological Research Institute, Mysore
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http://ir.cftri.com/9957/
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| Title |
Antiulcer And Anticancer Bioactive
Compounds From Ginger (Zingiber Officinale)
And Mango Ginger (Curcuma Amada)
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| Creator |
Siddaraju, M. N.
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| Subject |
30 Spices/Condiments
32 Antioxidants |
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| Description |
Ulcer is a common global problem with increasing incidence and prevalence. Worldwide 14.5
million people have ulcers with a mortality of 4.08 million. The increasing incidence and
prevalence of ulcers have been attributed to several factors encountered during day-to-day
life, such as stress, exposure to bacterial infection, and use of non-steroidal anti-inflammatory
drugs (NSAIDS). Ulcers are resulted from excess secretion of hydrochloric acid from gastric
parietal cells via activation of H+
, K+-ATPase enzyme, which releases the H+ into the lumen of
the stomach leading to acidity and the released acid act on gastric mucosa leading to loss of
mucosal protection. Gastric lesions thus develop due to loss of the delicate balance between
gastro-protective and aggressive factors. Reduction in gastric mucin, enhanced secretion of
gastric acid from parietal cells, enhanced susceptibility to Helicobacter pylori infection
aggravates the ulcer pathogenicity leading to severe gastric ulcers with heavy bleeding,
erosions, etc. Accumulated literature suggests that alcohol also play a major role in causing
gastric ulcers via portal hypertension. Further, long term ulcers were found to lead to cancers.
Sustainable efforts and constant research in the area lead to the development of several drugs
that can act at multi-steps during ulcer pathogenicity such as proton pump blockers
(Lansoprazole, Omeprazole), histamine receptor blockers (Ranitidine, Cimetidine, Famotidine)
and H. pylori Inhibitors (Amoxicillin, Erythromycin, Metronidazole), However, majority of them
have been documented with the pose of adverse effects.
Abstract
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In light of the above, it is pertinent to study natural products from food/plants as potentials
antiulcer compounds. In the current thesis therefore dietary components have been explored
as a potential effective and safer antiulcer compounds. Since stress induction has been known
to cause ulcer as well as cancers via free radical induced reactive oxygen species leading to
both nuclear and cellular damages, dietary sources rich in antioxidative properties have been
selected. Ginger (Zingiber officinale) and Mango ginger (Curcuma amada) have been known
to exhibit potential health beneficial properties against various disorders in traditional
medicine.
Accordingly antiulcer and anticancer compounds have been addressed from ginger and
mango ginger by proposing the research topic entitled “Antiulcer and anticancer bioactive
compounds from ginger (Zingiber officinale) and mango ginger (Curcuma amada)”. Results of
the study suggested the role of antioxidants, particularly phenolic acids and pectic
polysaccharides that are effective in prevention and healing of ulcers at multi-steps of ulcer
pathogenicity as indicated in Scheme -1. Fractions of ginger and mango ginger showed multipotent
antiulcer (Chapter 2 & 3) and anticancer (Chapter 4) properties including inhibition of
H+
, K+-ATPase, inhibition of H. pylori growth, exhibiting antioxidant, antiproliferative and DNA
protective potentials. Thus antioxidant and pectic polysaccharide fractions of ginger and
mango ginger have been found to be effective antiulcer/anticancer alternatives
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| Contributor |
Shylaja, M Dharmesh
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| Date |
2008
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| Type |
Thesis
NonPeerReviewed |
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| Format |
application/pdf
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| Language |
en
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| Identifier |
http://ir.cftri.com/9957/1/siddaraju.pdf
Siddaraju, M. N. (2008) Antiulcer And Anticancer Bioactive Compounds From Ginger (Zingiber Officinale) And Mango Ginger (Curcuma Amada). Doctoral thesis, University of Mysore. |
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