Ameliorative effect of zinc supplementation on compromised small intestinal health in streptozotocin-induced diabetic rats.
IR@CFTRI: CSIR-Central Food Technological Research Institute, Mysore
View Archive Info| Field | Value | |
| Relation |
http://ir.cftri.com/14099/
https://doi.org/10.1016/j.cbi.2019.04.018 |
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| Title |
Ameliorative effect of zinc supplementation on compromised small intestinal health in
streptozotocin-induced diabetic rats.
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| Creator |
Susmita, Barman
Srinivasan, K. |
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| Subject |
04 Diabetes Mellitus
04 Vitamins |
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| Description |
Zinc depletion during diabetes postulates a role for zinc nutrition in the management of
associated complications. The present study evaluated zinc supplementation for countering the
compromised intestinal integrity through moderation of oxidative stress and suppression of
stress-stimulated inflammatory proliferation in streptozotocin-induced diabetic rats. Diabetic rats
were provided with supplemental zinc for six weeks (5 and 10-times of normal level).
Supplemental zinc nurtured diabetic groups evidenced a significant reversal of the disruption of
intestinal ultra structure. While the brush border membrane (BBM) of diabetic animals showed
decreased fluidity with increased cholesterol: phospholipid ratio and altered polyunsaturated to
saturated fatty acid ratio, the same was countered in zinc supplementation. A stimulated activity
of BBM-bound enzymes suggested a modulation in membrane dynamics in diabetic condition
which was moderated in zinc treatment. Higher expression of the lipid oxidative markers,
oxidative stress markers, concomitant inflammatory markers, cytokines, fibrosis factors and
apoptotic regulatory proteins in the intestines were curbed by zinc supplementation. The
pathological aberrations of the intestinal architecture in diabetic animals were similarly reverted.
Thus, supplemental zinc has a favourable consequence in restricting the compromised intestinal
health in diabetes which was exerted through a defensive stimulus on oxidative stress induced
cytokines, inflammatory propagation and subsequent injury.
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| Date |
2019
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| Type |
Article
PeerReviewed |
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| Format |
pdf
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| Language |
en
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| Identifier |
http://ir.cftri.com/14099/1/Chemico-Biological%20Interactions%20%282019%29.pdf
Susmita, Barman and Srinivasan, K. (2019) Ameliorative effect of zinc supplementation on compromised small intestinal health in streptozotocin-induced diabetic rats. Chemico-Biological Interactions (307). pp. 37-50. ISSN 0009-2797 |
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