cAMP-PKA dependent ERK1/2 activation is necessary for vanillic acid potentiated glucose-stimulated insulin secretion in pancreatic β-cells.
IR@CFTRI: CSIR-Central Food Technological Research Institute, Mysore
View Archive Info| Field | Value | |
| Relation |
http://ir.cftri.com/14118/
https://doi.org/10.1016/j.jff.2019.02.047 |
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| Title |
cAMP-PKA dependent ERK1/2 activation is necessary for vanillic acid
potentiated glucose-stimulated insulin secretion in pancreatic β-cells.
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| Creator |
Mahendra, V. P.
Devendra, J. Haware Ravi, Kumar |
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| Subject |
10 Plants
04 Diabetes Mellitus |
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| Description |
Vanillic acid (VA), a dietary phenolic compound is generally studied for its anti-oxidative and anti-inflammatory
effects. However, the effect of VA on insulin secretion and its mechanism of action has never been explored. In
this study, we report that VA augments glucose-stimulated insulin secretion (GSIS) in both insulin-secreting cellline
INS-1 and isolated rat pancreatic islets. Potentiation of GSIS is accompanied by a concurrent increase in
3′,5′-cyclic adenosine monophosphate (cAMP) and activation of protein kinase A (PKA) in INS-1 and rat islets.
The activated cAMP-PKA pathway, in turn, phosphorylates extracellular signal-regulated kinases 1/2 (ERK1/2)
in INS-1 cells. Pharmacological intervention with PKA and ERK1/2 inhibitors revealed that VA potentiated GSIS
is primarily dependent on PKA mediated ERK1/2 activity. These findings demonstrated that VA directly acts on
insulin-secreting pancreatic β-cells to exert its insulinotropic effect thereby providing a novel role of VA in the
regulation of insulin secretion.
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| Publisher |
Elsevier
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| Date |
2019
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| Type |
Article
PeerReviewed |
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| Format |
pdf
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| Language |
en
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| Identifier |
http://ir.cftri.com/14118/1/Journal%20of%20Functional%20Foods%2056%20%282019%29%20110%E2%80%93118.pdf
Mahendra, V. P. and Devendra, J. Haware and Ravi, Kumar (2019) cAMP-PKA dependent ERK1/2 activation is necessary for vanillic acid potentiated glucose-stimulated insulin secretion in pancreatic β-cells. Journal of Functional Foods, 56. pp. 110-118. ISSN 1756-4646 |
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