Structural and functional characterization of new pigment molecule Monashin from Monascus purpureus CFR410-11.
IR@CFTRI: CSIR-Central Food Technological Research Institute, Mysore
View Archive Info| Field | Value | |
| Relation |
http://ir.cftri.com/14205/
https://doi.org/10.1016/j.procbio.2019.04.004 |
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| Title |
Structural and functional characterization of new pigment molecule
Monashin from Monascus purpureus CFR410-11.
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| Creator |
Saikat, Mondal
Saritha, G. Pandit Mohan Kumari, H. P. Nanishankar, V. Harohally Mohan, A. Dhale |
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| Subject |
02 Fungi
32 Antioxidants |
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| Description |
Biosynthetic pathway of Monascus pigment production is very complex. The mutant, M.
purpureus CFR410-11 has produced new monacolin and subsequently it was predicted to
produce new pigment molecule as well. Accordingly a pigment molecule was isolated by
employing silica gel column chromatography. The TLC and HPLC data revealed the purity of
isolated pigment molecule. The interpretation of UV-visible, NMR and HRMS spectra of the
pigment lead to its identity as 10-Hydroxy-3-(Prop-1-en-1-yl)-5-undecanoyl-10,10a-1Hbenzo(
g)isochromene-8-carbaldehyde and designated as monashin. Apparently, the production of
new derivative of pigment molecule is due to the changes in biosynthetic pathway caused by the
mutation or reduction, oxidation of other molecules. The pigment monashin exhibited the DPPH
(26%), H2O2 (77%), and reducing power (0.57 AU) activity at 37.5, 40 and 46.15μg/ml
concentration respectively. These antioxidant functions suggested the biological importance of
monashin.
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| Date |
2019
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| Type |
Article
PeerReviewed |
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| Format |
pdf
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| Language |
en
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| Identifier |
http://ir.cftri.com/14205/1/Process%20Biochemistry%202019.pdf
Saikat, Mondal and Saritha, G. Pandit and Mohan Kumari, H. P. and Nanishankar, V. Harohally and Mohan, A. Dhale (2019) Structural and functional characterization of new pigment molecule Monashin from Monascus purpureus CFR410-11. Process Biochemistry, 82. pp. 173-178. ISSN 1359-5113 |
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