Prophylactic neuroprotective propensity of Crocin, a carotenoid against rotenone induced neurotoxicity in mice: behavioural and biochemical evidence.
IR@CFTRI: CSIR-Central Food Technological Research Institute, Mysore
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| Relation |
http://ir.cftri.com/14220/
https://doi.org/10.1007/s11011-019-00451-y |
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| Title |
Prophylactic neuroprotective propensity of Crocin, a carotenoid against rotenone induced neurotoxicity in mice: behavioural and biochemical evidence.
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| Creator |
Sriranjini, Venkata Rao
Hemalatha, P. Yetish, S. Muralidhara, M. Rajini, P. S. |
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| Subject |
14 Carotenoid Chemistry
17 Toxicology |
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| Description |
Previously we have demonstrated the potential neuroprotective propensity of saffron and Crocin (CR) employing a Drosophila model of Parkinsonism. Rotenone (ROT) has been extensively used as a model neurotoxin to induce Parkinson’s disease (PD) likesymptomsinmice.In the present study,as a proof of conceptweevaluatedtheefficacyofCRprophylaxis(25mg/kgbw/d, 7d) toattenuate ROT(0.5mg/Kg bw/d,7d) -inducedneurotoxiceffects inmalemicefocussing onneurobehaviouralassessments andbiochemical determinantsinthestriatum.CRprophylaxissignificantlyalleviatedROT-inducedbehaviouralalterationssuch as increased anxiety, diminished exploratory behaviour, decreased motor co-ordination, and grip strength. Concomitantly, we evidenceddiminutionofoxidative stressmarkers,enhancedlevelsofantioxidant enzymeand mitochondrialenzymefunctionin the striatalregion. Further, varying degreeofrestoration ofcholinergic function, dopamineand α-synucleinlevelswerediscerniblesuggestingthepossiblemechanism/sofactionofCRinthismodel.Basedonourearlierdatainfliesandinwormmodel,we propose its use as an adjuvant therapeutic agent in oxidative stress-mediated neurodegenerative conditions such as PD.
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| Date |
2019
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| Type |
Article
PeerReviewed |
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| Format |
pdf
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| Language |
en
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| Identifier |
http://ir.cftri.com/14220/1/Metabolic%20Brain%20Disease%20%282020%29%20341341%E2%80%931353.pdf
Sriranjini, Venkata Rao and Hemalatha, P. and Yetish, S. and Muralidhara, M. and Rajini, P. S. (2019) Prophylactic neuroprotective propensity of Crocin, a carotenoid against rotenone induced neurotoxicity in mice: behavioural and biochemical evidence. Metabolic Brain Disease, 34. pp. 1341-1353. |
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