Lectin rich horsegram protein and myricetin activates insulin signaling – A study targeting PTP1β.
IR@CFTRI: CSIR-Central Food Technological Research Institute, Mysore
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| Relation |
http://ir.cftri.com/14259/
https://doi.org/10.1016/j.jff.2020.103845 |
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| Title |
Lectin rich horsegram protein and myricetin activates insulin signaling – A
study targeting PTP1β.
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| Creator |
Lalitha, N.
Sadashivaiah, B. Ramaprasad, T. R. Sridevi Annapurna, Singh |
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| Subject |
29 Protein Chemistry
22 Legumes-Pulses |
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| Description |
Horsegram, a rich source of myricetin (Myr), exhibits an anti-hyperglycemic effect. We examined the individual
and combinational effect of Myr and horsegram protein (HP) on protein tyrosine phosphatase 1β (PTP1β), and
its effect on insulin signaling in high-fat-diet (HFD) and a single dose of streptozotocin (STZ) induced diabetic rat
model. Myr, HP, and their combination, Myr + HP, were orally administered to diabetic animals for four weeks.
Myr, HP, and Myr + HP were effective in reducing elevated blood glucose, HbA1c, fasting insulin, insulin
resistance, oxidative stress markers, and proinflammatory cytokines. Myr ameliorated dyslipidemia and significantly
reduced PTP1β activity; HP and Myr + HP were not as effective, although they suppressed the expression
of PTP1β. Myr and HP treated groups had elevated levels of the phospho-insulin receptor (pIR),
phospho-insulin receptor substrate1 (pIRS1), and phospho-Akt (pAkt), whereas, Myr + HP was not effective.
Though myricetin and horsegram proteins ameliorate diabetic conditions, dietary intake of their combination
reduced individual efficiency.
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| Publisher |
Elsevier
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| Date |
2020
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| Type |
Article
PeerReviewed |
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| Format |
pdf
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| Language |
en
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| Identifier |
http://ir.cftri.com/14259/1/Journal%20of%20Functional%20Foods%2067%20%282020%29%20103845.pdf
Lalitha, N. and Sadashivaiah, B. and Ramaprasad, T. R. and Sridevi Annapurna, Singh (2020) Lectin rich horsegram protein and myricetin activates insulin signaling – A study targeting PTP1β. Journal of Functional Foods, 67. ISSN 1756-4646 |
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