Evaluation of anti-quorum sensing and antimutagenic activity of 2,3- unsaturated and 2,3-dideoxyglucosides of terpene phenols and alcohols.
IR@CFTRI: CSIR-Central Food Technological Research Institute, Mysore
View Archive Info| Field | Value | |
| Relation |
http://ir.cftri.com/14264/
https://doi.org/10.1016/j.lwt.2019.108987 |
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| Title |
Evaluation of anti-quorum sensing and antimutagenic activity of 2,3-
unsaturated and 2,3-dideoxyglucosides of terpene phenols and alcohols.
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| Creator |
James Bound, D.
Pushpa, S. Murthy Negi, P. S. Srinivas, P. |
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| Subject |
01 Analysis
30 Spices/Condiments |
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| Description |
The anti-quorum sensing property of terpene phenols/alcohols and their deoxyglucosides was evaluated qualitatively
against Pseudomonas aeruginosa and Chromobacterium violaceum by agar well diffusion method, and
their antimutagenic activity was tested by Ames test. The 2,3-unsaturated and 2,3-dideoxy 1-O-glucoside derivatives
demonstrated higher inhibitory zones compared to those for the parent molecules. MIC values indicated
that the derivatives of carvacrol (1.0–1.2 μmol/ml) and thymol (1.0–1.2 μmol/ml) were more effective than the
other compounds (1.2–2.0 μmol/ml). The anti-quorum sensing potential of derivatives was demonstrated by the
reduction in the production of pyocyanin (75–95%) and violacein (76–98%) at sub-MIC concentrations. The 2,3-
unsaturated 1-O-glucosides of carvacrol and thymol exhibited superior antimutagenic properties, and 2,3-unsaturated
1-O-glucoside of thymol showed 87.7% inhibition of MMS induced mutation in Salmonella typhimurium
TA 1538 at 1 μmol/plate concentration. The superior anti-quorum and antimutagenic activities exhibited by
these derivatives indicate their potential application as food preservatives.
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| Date |
2020
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| Type |
Article
PeerReviewed |
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| Format |
pdf
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| Language |
en
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| Identifier |
http://ir.cftri.com/14264/1/LWT%20-%20Food%20Science%20and%20Technology%20122%20%282020%29%20108987.pdf
James Bound, D. and Pushpa, S. Murthy and Negi, P. S. and Srinivas, P. (2020) Evaluation of anti-quorum sensing and antimutagenic activity of 2,3- unsaturated and 2,3-dideoxyglucosides of terpene phenols and alcohols. LWT - Food Science and Technology, 122. pp. 1-8. ISSN 0023-6438 |
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