Facile CAN catalyzed one pot synthesis of novel indol-5,8-pyrimido[4,5- d ]pyrimidine derivatives and their pharmacological study.
IR@CFTRI: CSIR-Central Food Technological Research Institute, Mysore
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| Relation |
http://ir.cftri.com/14273/
https://doi.org/10.1016/j.cdc.2019.100335 |
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| Title |
Facile CAN catalyzed one pot synthesis of novel indol-5,8-pyrimido[4,5- d ]pyrimidine derivatives and their pharmacological study.
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| Creator |
Venkatesh, T.
Yadav, D. Bodke Aditya Rao, S. J. |
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| Subject |
15 Pharmacology
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| Description |
In the present work a novel series of indol-5,8-pyrimido[4,5- d ]pyrimidine derivatives ( 4a-l ) have been synthesized by Biginelli reaction of barbituric/thiobarbituric acid, sub- stituted indole-3-carboxaldehyde and substituted aryl amines in aqueous ethanol using 10 mol% CAN as a catalyst. The synthesized compounds ( 4a-l) were evaluated for in vitro an- tibacterial and anticancer activities. In addition to this, in silico molecular docking studies was also performed to predict the binding interactions of synthetic molecules with appro- priate target molecules in connection to their antimicrobial and anti-cancer effects. Among the compounds tested, compounds 4d, 4 g and 4 h were found to have effective antibac- terial activity against the tested pathogens. The cytotoxicity studies of synthesized pyrimi- dine derivatives were found to be effective against K-562, HeLa, MCF-7 and Hepg-2 cancer cell lines.
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| Date |
2020
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| Type |
Article
PeerReviewed |
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| Format |
pdf
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| Language |
en
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| Identifier |
http://ir.cftri.com/14273/1/Chemical%20Data%20Collections%2025%20%282020%29%20100335.pdf
Venkatesh, T. and Yadav, D. Bodke and Aditya Rao, S. J. (2020) Facile CAN catalyzed one pot synthesis of novel indol-5,8-pyrimido[4,5- d ]pyrimidine derivatives and their pharmacological study. Chemical Data Collections, 25. pp. 1-13. |
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