Withaferin-A down-regulate enterohepatic circulation of bile acids: An insight from a hyperlipidemic rat model.
IR@CFTRI: CSIR-Central Food Technological Research Institute, Mysore
View Archive Info| Field | Value | |
| Relation |
http://ir.cftri.com/14275/
https://doi.org/10.1016/j.jafr.2020.100035 |
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| Title |
Withaferin-A down-regulate enterohepatic circulation of bile acids: An
insight from a hyperlipidemic rat model.
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| Creator |
Pooja, Acharya
Parvati, H. Sadashivaiah, B. Mehrdad, Zarei Vinayak, Uppin Nayana, Venugopal Ramaprasad, T. R. |
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| Subject |
04 Diabetes Mellitus
04 Medicinal Plants |
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| Description |
Hyperlipidemia is a metabolic abnormality in both young and aged populations across the world. Withaferin-A
(WT) present in Withania somnifera (Indian ginseng) has been studied by many investigators for their therapeutic
potentials. However, their effects on bile acid (BA) metabolism, that play a significant role in lipid homeostasis
under hyperlipidemia has not been studied. This study explores the modulatory potential of WT on BA metabolism
in young and aged hyperlipidemic rats. Hyperlipidemia was induced by feeding lard fat (35g/100g diet,
HF) for 60 days. Withaferin-A (2.5 mg/kg diet) was fed to assess its effect on lipid metabolism and enterohepatic
circulation of BA. In both models, compared to HF, WT had significantly (p < 0.05), decreased serum lipids, BA
uptake, and HMG-CoA reductase activity, but increased hepatic Cyp7a1, decreased serum BA and increased fecal
BA. WT re-regulated hyperlipidemia-induced aberrations in the intestinal uptake, hepatic synthesis, and cholesterol
and BA metabolism in both models.
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| Date |
2020
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| Type |
Article
PeerReviewed |
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| Format |
pdf
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| Language |
en
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| Identifier |
http://ir.cftri.com/14275/1/Journal%20of%20Agriculture%20and%20Food%20Research%202%20%282020%29%20100035.pdf
Pooja, Acharya and Parvati, H. and Sadashivaiah, B. and Mehrdad, Zarei and Vinayak, Uppin and Nayana, Venugopal and Ramaprasad, T. R. (2020) Withaferin-A down-regulate enterohepatic circulation of bile acids: An insight from a hyperlipidemic rat model. Journal of Agriculture and Food Research, 2. pp. 1-6. |
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