Alteration of superhelical state of DNA by aluminium (Al).
IR@CFTRI: CSIR-Central Food Technological Research Institute, Mysore
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http://ir.cftri.com/2292/
BBA-04-93 |
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| Title |
Alteration of superhelical state of DNA by aluminium (Al).
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| Creator |
Rao, K. S.
Rao, B. S. Vishnuvardhan, D. Prasad, K. V. |
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| Subject |
03 Biochemistry & Molecular Biology
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| Description |
The effect of aluminium (Al) on the supercoiled state of pUC18 DNA was studied by ethidium bromide fluorescence and agarose gel electrophoresis. Al at physiologically relevant concentrations relaxed the intact supercoiled DNA as well as the topoisomers induced by chloroquine. EDTA prevented the unwinding effect of Al on supercoiled DNA. Al did not alter the mobility of linear DNA in agarose gels. The implications of this finding in neurological disorders are discussed.
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| Date |
1993
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Language |
en
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| Rights |
—
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| Identifier |
http://ir.cftri.com/2292/1/Biochimica_et_Biophysica_Acta_%28BBA%29_-_Gene_Structure_and_Expression%2C_Volume_1172%2C_Issues_1-2%2C_20_February_1993%2C_Pages_17-20.pdf
Rao, K. S. and Rao, B. S. and Vishnuvardhan, D. and Prasad, K. V. (1993) Alteration of superhelical state of DNA by aluminium (Al). Biochimica et Biophysica Acta, 1172 (1-2). pp. 17-20. ISSN 0006-3002 |
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