Turmerin: a water soluble antioxidant peptide from turmeric [Curcuma longa]
IR@CFTRI: CSIR-Central Food Technological Research Institute, Mysore
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| Relation |
http://ir.cftri.com/2319/
ABB-06-92 |
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| Title |
Turmerin: a water soluble antioxidant peptide from turmeric [Curcuma longa]
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| Creator |
Srinivas, L.
Shalini, V. K. Shylaja, M. |
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| Subject |
07 Turmeric
32 Antioxidants |
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| Description |
Dietary spice components have been screened for their protective effect against reactive oxygen species (ROS)-induced, lipid peroxide-mediated membrane and DNA damage and mutagenecity. A new, water soluble, 5-kDa peptide--Turmerin--from turmeric (Curcuma longa) has been found to be an efficient antioxidant/DNA-protectant/antimutagen. Turmerin forms 0.1% of the dry weight of turmeric and is obtained in a crystalline form. It is a heat stable, noncyclic peptide containing 40 amino acid residues, with a blocked N-terminal and leucine at the C-terminal. It is insensitive to trypsin and pepsin, heat, and uv radiation. Turmerin contains three residues of methionine which are partly responsible for the antioxidant activity. Turmerin at 183 nM offers 80% protection to membranes and DNA against oxidative injury. ROS-induced arachidonate release and the mutagenic activity of t-butyl hydroperoxide are substantially inhibited by Turmerin. Tumerin is noncytotoxic up to milligram concentrations, as tested by Ames assay and in human lymphocytes.
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| Date |
1992
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Language |
en
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| Identifier |
http://ir.cftri.com/2319/1/Archives_of_Biochemistry_and_Biophysics%2C_Volume_292%2C_Issue_2%2C_1_February_1992%2C_Pages_617-623.pdf
Srinivas, L. and Shalini, V. K. and Shylaja, M. (1992) Turmerin: a water soluble antioxidant peptide from turmeric [Curcuma longa]. Archives of Biochemistry and Biophysics, 292 (2). pp. 617-23. ISSN 0003-9861 |
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