In vitro studies on the intestinal absorption of curcumin in rats.
IR@CFTRI: CSIR-Central Food Technological Research Institute, Mysore
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| Relation |
http://ir.cftri.com/2418/
Tox-01-81 |
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| Title |
In vitro studies on the intestinal absorption of curcumin in rats.
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| Creator |
Vijayalakshmi, R.
Chandrashekara, N. |
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| Subject |
07 Turmeric
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| Description |
When everted sacs of rat intestines were incubated with 50--750 ~g of
curcumin in 10 ml incubation medium, 30--80% of the added curcumin
disappeared from the mucosal side. No curcumin was however detectable
in the serosal fluid. Less than 3% of the added curcumin was found in the
tissue at the highest concentration. In experiments with [aH]curcumin,
5--6% of added radioactivity was found in the serosal side. TLC examination
of the mucosal extract showed the presence of 2 compounds, 1 corresponding
to curcumin and the other to a less polar, colourless compound. The serosal
fluid had no curcumin but a compound whose RF was identical with the
colourless compound present in the mucosal side. These experiments indicated
that curcumin undergoes transformation during absorption from the
intestine.
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| Date |
1981
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Language |
en
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| Rights |
—
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| Identifier |
http://ir.cftri.com/2418/1/Toxicology%2C_Volume_20%2C_Issues_2-3%2C_1981%2C_Pages_251-257.pdf
Vijayalakshmi, R. and Chandrashekara, N. (1981) In vitro studies on the intestinal absorption of curcumin in rats. Toxicology, 20. pp. 251-257. |
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