Absorption and tissue distribution of curcumin in rats.
IR@CFTRI: CSIR-Central Food Technological Research Institute, Mysore
View Archive Info| Field | Value | |
| Relation |
http://ir.cftri.com/2632/
TOX-02-80 |
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| Title |
Absorption and tissue distribution of curcumin in rats.
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| Creator |
Vijayalakshmi, R.
Chandrashekara, N. |
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| Subject |
30 Spices/Condiments
09 Human Physiology |
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| Description |
After oral administration of 400 mg curcumin to rats, about 60% of the
dose was absorbed. No curcumin was detectable in urine. The urinary excretion
of conjugated glucuronides and sulfates significantly increased. No
curcumin was present in heart blood. Only traces (less than 5 ~g/ml) in
portal blood and negligible quantities in liver and kidney (<~ 20 ~g/tissue)
were observed from 15 rain upto 24 h after administration of curcumin. At
the end of 24 h the concentration of curcumin remaining in the lower part
of the gut namely caecum and large intestine amounted to 38% of the
quantity administered.
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| Date |
1980
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Language |
en
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| Rights |
—
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| Identifier |
http://ir.cftri.com/2632/1/Toxicology%2C_Volume_16%2C_Issue_3%2C_1980%2C_Pages_259-265.pdf
Vijayalakshmi, R. and Chandrashekara, N. (1980) Absorption and tissue distribution of curcumin in rats. Toxicology, 16. pp. 259-265. |
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